Vanilloid receptor TRPV1 in drug discovery targeting pain and other pathological disorders

Publication/Creation:

Hoboken, NJ : Wiley, c2010

Resource Type:

Book

More Details

Additional/Related Title Information

Full Title:

Vanilloid receptor TRPV1 in drug discovery targeting pain and other pathological disorders / edited by Arthur Gomtsyan, Connie R. Faltynek

Related Names

Additional Author/Creators:

Gomtsyan, Arthur
Faltynek, Connie R.

Subjects/Genre

Subjects:

Analgesics
Drugs--Design
Nociceptors
Inflammation

Description/Summary

Table of Contents:

VANILLOID RECEPTOR TRPV1 IN DRUG DISCOVERY; CONTENTS; PREFACE AND ACKNOWLEDGMENTS; FOREWORD; CONTRIBUTORS; PART I INTRODUCTION TO THE TRP CHANNELS; 1 TRP Channels and Human Diseases; 2 Role of TRP Channels in Pain: An Overview; 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals; 4 TRPV1 Genetics; PART II ROLE FOR TRPV1 IN PAIN STATES; 5 TRPV1 and Inflammatory Pain; 6 Role of TRPV1 Receptors in Osteoarthritic Pain; 7 TRPV1 and Bone Cancer Pain; 8 TRPV1 in Visceral Pain and Other Visceral Disorders; 9 TRPV1 Receptors and Migraine
10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS; 11 Aryl-Urea Class and Related TRPV1 Antagonists; 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists; 13 TRPV1 Agonist Approaches for Pain Management; PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION; 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?; 15 The Role of TRPV1 in Respiratory Diseases; 16 The Role of TRPV1 in Diabetes; AFTERWORD
INDEX

Summary:

Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it ""the holy grail"" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1

Language:

English

Language Note:

English

Physical Type/Description:

1 online resource (486 p.)

General Note:

Description based upon print version of record.

Additional Identifiers

Catalog ID (MMSID):

9936533638602486

ISBN:

1-282-55159-0
9786612551598
0-470-58828-4
0-470-58827-6

OCLC Number:

587063581